Epigenomic programming in early fetal brain development
نویسندگان
چکیده
منابع مشابه
Growth and Development: Early Development and Fetal Programming
J. Anim. Sci. Vol. 88, E-Suppl. 2/J. Dairy Sci. Vol. 93, E-Suppl. 1/Poult. Sci. Vol. 89, E-Suppl. 1 635 Evaluation of the NCAPG I442M locus, a major gene for bovine prenatal growth, for effects on postnatal development compared to a disruptive mutation in the myostatin encoding gene GDF8. C. Kuehn*, P. Widmann, R. Pfuhl, and R. Weikard, Leibniz Institute for Farm Animal Biology (FBN), Dummersto...
متن کاملCerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain.
Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral organoids and human fetal brain, using genome-wide, base resolution DNA methylome and transcripto...
متن کاملGlobal epigenomic reconfiguration during mammalian brain development.
DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with ...
متن کاملEarly oleate deficiency leads to severe defects in fetal rat liver development
Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat ...
متن کاملPregnancy, embryo-fetal development and nutrition: physiology around fetal programming
The purpose of this brief narrative review is to highlight the role of nutrition during the gestation period. We focused on the possible effects of imbalance of some nutrients in normal course of pregnancy and embryonic development. We discussed about changes in nutritional and/or hormonal embryonic microenvironment, which represent the basis of a phenomenon known as “fetal programming”. We str...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epigenomics
سال: 2020
ISSN: 1750-1911,1750-192X
DOI: 10.2217/epi-2019-0319